Panthers quarterback Cam Newton vs. Saints defensive coordinator Gregg Williams -- Williams is one of the best at scheming against rookie quarterbacks. He fooled Blaine Gabbert some last week, causing one interception, and look for him to try to do the same to Newton. In his first four games, Newton has made some big plays but he's also made some rookie mistakes. If he can avoid them here, he could have another big game.
Lions left tackle Jeff Backus vs. Bears defensive end Julius Peppers -- Backus did a decent job on DeMarcus Ware last week after having a rough go of it against Jared Allen the week before. Peppers is another tough challenge. Peppers didn't do much against Jordan Gross last week, so this is another chance to make some noise in the opposing backfield.
Lions right end Cliff Avril vs. Bears right tackle Lance Louis -- Avril is one of the better pass rushers in the league. He has speed and power. Louis has started at guard, but moved to right tackle last week in the second half and did a nice job in place of Frank Omiyale. This will be a tough test for Louis.
Packers tight end Jermichael Finley vs. Falcons safeties Thomas DeCoud and William Moore -- Finley is off to a torrid start for the Packers. He is a move tight end who can stretch a defense. He will put a lot of pressure on DeCoud and Moore, two younger safeties who have to play better. They have ability, but for some reason they haven't played as well as expected.
Patriots receiver Wes Welker vs. Jets corners (maybe Darrelle Revis) -- The Jets did a great job on the Patriots offense in the playoff game last January. But Welker is lighting up every secondary he faces. The Jets might put Revis on him some, which would be a change. He's on pace for 140 catches, so they have to do something.
Steelers outside linebacker LaMarr Woodley vs. Titans offensive tackle David Stewart -- With James Harrison out for the Steelers, Woodley has to come up big pressuring Matt Hasselbeck. The Titans have protected Hasselbeck pretty well this season, but the Steelers can get after him some if Woodley can win against Stewart, who is one of the better right tackles in the league.
Raiders left tackle Jared Veldheer vs. Texans outside linebacker Mario Williams -- Williams had two sacks last week against the Steelers and has done a nice job adjusting to the move to outside linebacker. Veldheer has been one of the better left tackles in the league this season, his second in the league. This should be a good one to watch.
Giants defensive end Jason Pierre-Paul vs. Seahawks left tackle Russell Okung -- Pierre-Paul is having his breakout season in his second in the league. He is an explosive edge player who also plays the run well. Okung is also a second-year player. He has improved from last season, but he still has a way to go. If he can neutralize Pierre-Paul, it would go a long way to improving his reputation.
Falcons center Todd McClure or Joe Hawley vs. Packers nose tackle B.J. Raji -- If the Falcons want to get the running game going, they have to handle Raji. That means McClure or Hawley, depending on McClure's knee, have to be physical at the point. Neither is considered strong in the run game, so this could be trouble for Michael Turner.
Bills WR Stevie Johnson vs. Eagles corner Nnamdi Asomugha -- There's been a lot of talk that Asomugha hasn't played that well. That's not true. He just hasn't played to his normal standards. Johnson is off to a fast start and he's the Bills best receiver. The Bills are rolling on offense, so this could be a shootout. Can Asomugha handle Johnson? Will he even play him in man?