Bears defensive end Julius Peppers vs. Raiders left tackle Jared Veldheer -- Veldheer is coming off an impressive game against Jared Allen, holding him without a sack and to just two tackles.  Now he gets Peppers. What a two-game workload. This should be a real treat. Peppers also can play the run. If Oakland is to get the running game going, Veldheer has to handle him.

Colts defensive end Dwight Freeney vs. Panthers tackle Jordan Gross --Freeney is considered one of the game's best speed rushers, but he hasn't put up the sack numbers this season with the Colts rarely playing with the lead. Gross is a top-level pass protector who helps make the Panthers offense go. Gross can't let Freeney get it going. Then again, that would mean the Colts would likely have the lead, which they haven't had much this season.

Giants defensive ends vs. Saints tackles -- We've seen the Saints tackles struggle -- see St. Louis -- and it really impacted the offense. The Giants defensive line didn't do much last week against the Eagles, but with Jason Pierre-Paul and Justin Tuck and Osi Umenyiora, they're capable of really getting after it. That will put a lot of pressure on Jermon Bushrod and Zach Strief to protect Drew Brees.

Bengals receiver A.J. Green vs. Browns cornerback Joe Haden -- These two faced off in college when Green was at Georgia and Haden at Florida. Green is coming back after missing last week with a leg injury. Haden played a lot of man last week against the Jaguars and was hit with two pass-interference penalties. But he has had a good season and he should spend the day on Green.

Steelers receiver Mike Wallace vs. Chiefs cornerback Brandon Flowers -- Flowers has battled back after a slow start to have a good season. That doesn't mean he won't be beat, but he plays a lot of man coverage. That's risky against Wallace, who can fly. He might be the fastest receiver in the NFL. One mistake and it will be a 70-yard touchdown.

Eagles defensive end Jason Babin vs. Patriots tackle Sebastian Vollmer -- Vollmer had big problems early last week with Tamba Hali of the Chiefs. Babin might not be as explosive as Hali, but he is a relentless player who doesn't quit. He will be there all day long.

Patriots tight end Rob Gronkowski vs. Eagles safeties Kurt Coleman and Nate Allen -- Gronkowski is one of the best tight ends in the game. He has 10 touchdown catches and present big problems for smaller safeties, but is too fast for linebackers. Coleman isn't great in coverage, but Allen is pretty good. If Coleman gets matched up on Gronkowski, it could be trouble for the Eagles.